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MDS & Myeloproliferative Neoplasms

December 20, 2021

A collection of features and news articles published in ASH Clinical News related to myelodysplastic syndromes and myeloproliferative neoplasms.

IPSS That Incorporates Gene Mutations Offers Better Risk Stratification for MDS

An updated International Prognosis Scoring System (IPSS) for myelodysplastic syndromes (MDS) that considers gene mutations (IPSS-M) led to improved discrimination compared with the revised...

Germline Variants in DNA Repair Pathway Genes May Trigger Familial MPNs

Germline variants in DNA repair pathway genes, such as BRCA1/2, may trigger familial myeloproliferative neoplasms (MPNs), suggesting these variants should be incorporated in diagnostic...

New Prognostic Model Outperforms Established Predictive Models in MDS

In a study published in the Journal of Clinical Oncology, researchers reported that a newly developed personalized prediction model comprising clinical and genomic data...

Reduced-Intensity Conditioning Transplant Superior to Continuous 5-Azacitidine in Older Patients With MDS

In older patients with advanced myelodysplastic syndromes (MDS), reduced-intensity conditioning allogeneic hematopoietic cell transplantation (HCT) improved event-free survival (EFS) compared with continuous 5-azacitidine therapy....


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