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VLX-1005 Receives Orphan Drug Designation

December 30, 2021

The FDA granted orphan drug designation to VLX-1005 as thrombosis prophylaxis in patients with heparin-induced thrombocytopenia (HIT).

According to its manufacturer, Veralox Therapeutics, preclinical data have shown that VLX-1005 has the potential to halt immune-driven platelet activation and thrombosis. VLX-1005 is a first-in-class, selective small molecule inhibitor of 12-lipoxygenase, a key target within the arachidonic acid pathway.

"We believe VLX-1005 has great potential to be the first disease modifying therapy for HIT in over 20 years," said Matthew B. Boxer, PhD, chief operating officer of Veralox Therapeutics.

Source: Veralox Therapeutics press release, January 26, 2021.

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